Protein Transduction Domain (PTD) Technology.

Madenco’s core patented transdermal delivery technologies consist Protein Transduction Domain (PTD) technology and Polymeric Nanoparticles (PLGA) for cosmetic, dermatology and pharmaceutical applications.

Madenco is focused on becoming a global leader in the development of transdermal skin penetrative active materials for cosmetics and pharmaceuticals.

    • Protein Transduction Domain (PTD)
    • PTD technology enables the effective transfer of macromolecules such as proteins, DNA and peptides into the dermis.
    • PTD technology is far superior for transport of native proteins to enhance permeability

Fusion protein-01

Encapsulated protein by conventional liposome

Fusion protein-02

Encapsulated protein by PDT across linked liposome

Fusion protein-03

Linked fusion protein

    • Superior to liposomal formulations
    • This patented PTD technology has broad applications in Dermatology, Rx Pharma and Consumer Health products

Polymeric Nanoparticles (PLGA)


It is important to note that large molecules such as proteins and peptides are typically not good candidates for topical and transdermal delivery unless their transport can be facilitated by technologies such as Madenco’s PTD or PLGA Nanoparticles. Our Polymeric nanoparticle technology is patented and is capable for the development of formulations of a wide range of drug molecules for both topical and parenteral administration. This technology is particularly suitable for non-soluble compounds and similar to the PDT technology, far superior to liposomes.


Bellus Skin Cosmetics

Since the wound healing properties of Nobel Prize winning EGF (Epidermal Growth Factor), EGF has been used as a main ingredient in several luxury brand cosmetic products yet EGF is known to have poor permeability into the skin.

skin renewal

At the core of these products Bellus Skin incorporates the PTD technology

(SP1-EGF & SP1-FGF1)

Bellus Skin Rejuvenation Serum contains BOTH SP1-EGF and SP1-FGF1 Skin Permeable Essential Growth Factors
Utilizes Protein Transduction Domain (PTD) patented technology.
Science based-clinically proven anti-aging skin serum

Initial product(s)
3 x 10 ml / 1x 10 ml Bellus Skin Rejuvenation Serum

Madenco will be launching the Bellus Skin Brand of cosmetic products in 2016.